Structure analysis

Protein kinase A fivefold mutant model of Rho-kinase with Y-27632

X-ray diffraction
2.28Å resolution
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 16571.44 Å2
Buried surface area: 2793.98 Å2
Dissociation area: 1,107.2 Å2
Dissociation energy (ΔGdiss): 4.91 kcal/mol
Dissociation entropy (TΔSdiss): 9.23 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132592

Macromolecules

Chain: A
Length: 350 amino acids
Theoretical weight: 40.7 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00517 (Residues: 2-351; Coverage: 100%)
Gene name: PRKACA
Pfam: Protein kinase domain
InterPro:
CATH:

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Chain: I
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P63248 (Residues: 6-25; Coverage: 26%)
Gene name: Pkia
InterPro: cAMP-dependent protein kinase inhibitor

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