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REFINED ATOMIC MODEL OF GLUTAMINE SYNTHETASE AT 3.5 ANGSTROMS RESOLUTION

Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Biochemical function: metal ion binding
Biological process: protein homooligomerization
Cellular component: membrane

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EC 6.3.1.2: Glutamine synthetase

Reaction catalysed:
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine
Systematic name:
L-glutamate:ammonia ligase (ADP-forming)
Alternative Name(s):
  • Glutamate--ammonia ligase
  • Glutamylhydroxamic synthetase
  • L-glutamine synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00120
Domain description: Glutamine synthetase, catalytic domain
Occurring in:
  1. Glutamine synthetase
The deposited structure of PDB entry 2gls contains 12 copies of Pfam domain PF00120 (Glutamine synthetase, catalytic domain) in Glutamine synthetase. Showing 1 copy in chain A.

PF03951
Domain description: Glutamine synthetase, beta-Grasp domain
Occurring in:
  1. Glutamine synthetase
The deposited structure of PDB entry 2gls contains 12 copies of Pfam domain PF03951 (Glutamine synthetase, beta-Grasp domain) in Glutamine synthetase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008146
Domain description: Glutamine synthetase, catalytic domain
Occurring in:
  1. Glutamine synthetase
IPR008147
Domain description: Glutamine synthetase, N-terminal domain
Occurring in:
  1. Glutamine synthetase
IPR036651
Domain description: Glutamine synthetase, N-terminal domain superfamily
Occurring in:
  1. Glutamine synthetase
IPR001637
Domain description: Glutamine synthetase class-I, adenylation site
Occurring in:
  1. Glutamine synthetase
IPR027303
Domain description: Glutamine synthetase, glycine-rich site
Occurring in:
  1. Glutamine synthetase
IPR014746
Domain description: Glutamine synthetase/guanido kinase, catalytic domain
Occurring in:
  1. Glutamine synthetase
IPR027302
Domain description: Glutamine synthetase, N-terminal conserved site
Occurring in:
  1. Glutamine synthetase
IPR004809
Domain description: Glutamine synthetase type I
Occurring in:
  1. Glutamine synthetase

Structure domains

CATH CATH domains
3.30.590.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Creatine Kinase; Chain A, domain 2
Homology: Glutamine synthetase/guanido kinase, catalytic domain
Occurring in:
  1. Glutamine synthetase
The deposited structure of PDB entry 2gls contains 12 copies of CATH domain 3.30.590.10 (Creatine Kinase; Chain A, domain 2) in Glutamine synthetase. Showing 1 copy in chain A.
3.10.20.70
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Glutamine synthetase, N-terminal domain
Occurring in:
  1. Glutamine synthetase
The deposited structure of PDB entry 2gls contains 12 copies of CATH domain 3.10.20.70 (Ubiquitin-like (UB roll)) in Glutamine synthetase. Showing 1 copy in chain A.
SCOP SCOP annotations
55932
Class: Alpha and beta proteins (a+b)
Fold: Glutamine synthetase/guanido kinase
Superfamily: Glutamine synthetase/guanido kinase
Occurring in:
  1. Glutamine synthetase
The deposited structure of PDB entry 2gls contains 12 copies of SCOP domain 55932 (Glutamine synthetase catalytic domain) in Glutamine synthetase. Showing 1 copy in chain A.
54369
Class: Alpha and beta proteins (a+b)
Fold: beta-Grasp (ubiquitin-like)
Superfamily: Glutamine synthetase, N-terminal domain
Occurring in:
  1. Glutamine synthetase
The deposited structure of PDB entry 2gls contains 12 copies of SCOP domain 54369 (Glutamine synthetase, N-terminal domain) in Glutamine synthetase. Showing 1 copy in chain A.

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