X-ray diffraction
2.02Å resolution

Cytoplasmic Domain Structure of Kir2.1 containing Andersen's Mutation R218Q and Rescue Mutation T309K


Function and Biology Details

Structure analysis Details

Assemblies composition:
homo tetramer (preferred)
homo octamer
Entry contents:
1 distinct polypeptide molecule
Inward rectifier potassium channel 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 208 amino acids
Theoretical weight: 23.91 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: P35561 (Residues: 187-371; Coverage: 43%)
Gene names: Irk1, Kcnj2
Sequence domains: Inward rectifier potassium channel C-terminal domain
Structure domains: G protein-activated inward rectifier potassium channel 1

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2
Unit cell:
a: 140.674Å b: 98.876Å c: 98.094Å
α: 90° β: 130.68° γ: 90°
R R work R free
0.191 0.177 0.229
Expression system: Escherichia coli