› 2gil

X-ray diffraction
1.82Å resolution

Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution

Released:
DOI: 10.2210/pdb2gil/pdb
PDB entry 2gil coloured by chain, front view.
PDB entry 2gil coloured by chain, side view.
PDB entry 2gil coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution.
Bergbrede T, Pylypenko O, Rak A, Alexandrov K
J Struct Biol 152 235-8 (2005)
PMID: 16332443

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148952 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-6A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 162 amino acids
Theoretical weight: 18.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P20340 (Residues: 13-174; Coverage: 78%)
Gene names: RAB6, RAB6A
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 4 x MG
Ligand GTP 4 x GTP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 40.008Å b: 124.853Å c: 66.162Å
α: 90° β: 107.57° γ: 90°
R-values:
R R work R free
0.208 0.205 0.277
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity.
Pylypenko et al. (2018)
18 other articles

6 mentions without citation

Structural basis of membrane trafficking by Rab family small G protein.
Park HH. (2013)
5 more