X-ray diffraction
1.7Å resolution

Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I mutant: insights into the inhibitor design


Function and Biology Details

Reaction catalysed:
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Hypoxanthine phosphoribosyltransferase Chain: A
Molecule details ›
Chain: A
Length: 185 amino acids
Theoretical weight: 20.77 KDa
Source organism: Caldanaerobacter subterraneus subsp. tengcongensis
Expression system: Escherichia coli
  • Canonical: Q8R7L0 (Residues: 1-181; Coverage: 100%)
Gene names: Hpt, TTE2394
Sequence domains: Phosphoribosyl transferase domain
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: I222
Unit cell:
a: 52.21Å b: 88.36Å c: 93.03Å
α: 90° β: 90° γ: 90°
R R work R free
0.206 0.204 0.226
Expression system: Escherichia coli