› 2ga7

Solution NMR

Solution structure of the copper(I) form of the third metal-binding domain of ATP7A protein (menkes disease protein)

Released:
DOI: 10.2210/pdb2ga7/pdb
PDB entry 2ga7 coloured by chain, ensemble of 30 models, front view.
PDB entry 2ga7 coloured by chain, ensemble of 30 models, side view.
PDB entry 2ga7 coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure and intermolecular interactions of the third metal-binding domain of ATP7A, the Menkes disease protein.
Banci L, Bertini I, Cantini F, DellaMalva N, Herrmann T, Rosato A, Wüthrich K
J Biol Chem 281 29141-7 (2006)
PMID: 16873374

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170052 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Copper-transporting ATPase 1 Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 9.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q04656 (Residues: 275-352; Coverage: 5%)
Gene names: ATP7A, MC1, MNK
Sequence domains: Heavy-metal-associated domain
Structure domains: Alpha-Beta Plaits

Ligands and Environments

1 bound ligand:
Ligand CU1 1 x CU1
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Torsion angle dynamics coupled with simulated annealing followed by restrained energy minimization
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Function and regulation of human copper-transporting ATPases.
Lutsenko et al. (2007)
6 more

2 mentions without citation

Structural biology of copper trafficking.
Boal et al. (2009)
1 more