› 2g8g

X-ray diffraction
3.2Å resolution

Structurally mapping the diverse phenotype of Adeno-Associated Virus serotype 4

Released:
DOI: 10.2210/pdb2g8g/pdb
PDB 2g8g coloured by chain and viewed from the front.
PDB 2g8g coloured by chain and viewed from the side.
PDB 2g8g coloured by chain and viewed from the top.
Source organism: Adeno-associated virus - 4
Primary publication:
Structurally mapping the diverse phenotype of adeno-associated virus serotype 4.
Govindasamy L, Padron E, McKenna R, Muzyczka N, Kaludov N, Chiorini JA, Agbandje-McKenna M
J. Virol. 80 11556-70 (2006)
PMID: 16971437

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid Chain: A
Molecule details ›
Chain: A
Length: 524 amino acids
Theoretical weight: 58.44 KDa
Source organism: Adeno-associated virus - 4
Expression system: Escherichia coli
UniProt:
  • Canonical: O41855 (Residues: 211-734; Coverage: 71%)
Sequence domains: Parvovirus coat protein VP2
Structure domains: Parvovirus coat protein VP1/VP2

Ligands and Environments

1 bound ligand:
Ligand D5M 1 x D5M
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: I222
Unit cell:
a: 339.6Å b: 319.2Å c: 285Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.263 0.263 0.273
Expression system: Escherichia coli

Quick links

Citations

18 review citations

AAV Vector-Mediated Antibody Delivery (A-MAD) in the Central Nervous System.
Marino et al. (2022)
17 more

22 mentions without citation

Cryo-electron Microscopy of Adeno-associated Virus.
Stagg et al. (2022)
21 more