Function and Biology

Crystal structure of human DUSP5

Source organism: Homo sapiens
Biochemical function: protein tyrosine/serine/threonine phosphatase activity
Biological process: protein dephosphorylation
Cellular component: not assigned

EC 3.1.3.48: Protein-tyrosine-phosphatase

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Systematic name:
Protein-tyrosine-phosphate phosphohydrolase
Alternative Name(s):
  • (Phosphotyrosine)protein phosphatase
  • PPT-phosphatase
  • PTP-phosphatase
  • PTPase
  • Phosphoprotein phosphatase (phosphotyrosine)
  • Phosphotyrosine histone phosphatase
  • Phosphotyrosine phosphatase
  • Phosphotyrosine protein phosphatase
  • Phosphotyrosylprotein phosphatase
  • Protein phosphotyrosine phosphatase
  • Tyrosine O-phosphate phosphatase
  • Tyrosylprotein phosphatase

EC 3.1.3.16: Protein-serine/threonine phosphatase

Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Systematic name:
Phosphoprotein phosphohydrolase
Alternative Name(s):
  • 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
  • Aspergillus awamori acid protein phosphatase
  • BCKDH phosphatase
  • Branched-chain alpha-keto acid dehydrogenase phosphatase
  • Calcineurin
  • Casein phosphatase
  • HMG-CoA reductase phosphatase
  • Phosphatase 2A
  • Phosphatase 2B
  • Phosphatase C-II
  • Phosphatase H-II
  • Phosphatase I
  • Phosphatase IB
  • Phosphatase II
  • Phosphatase III
  • Phosphatase IV
  • Phosphatase SP
  • Phosphoprotein phosphatase
  • Phosphopyruvate dehydrogenase phosphatase
  • Phosphospectrin phosphatase
  • Polycation modulated (PCM-) phosphatase
  • Protein D phosphatase
  • Protein phosphatase
  • Protein phosphatase-1
  • Protein phosphatase-2A
  • Protein phosphatase-2B
  • Protein phosphatase-2C
  • Serine/threonine specific protein phosphatase

Sequence family

Pfam Protein family (Pfam)
PF00782
Domain description: Dual specificity phosphatase, catalytic domain
Occurring in:
  1. Dual specificity protein phosphatase 5
1 copy of Pfam domain PF00782 (Dual specificity phosphatase, catalytic domain) in Dual specificity protein phosphatase 5 in PDB 2g6z.

InterPro InterPro annotations
IPR020417
Domain description: Atypical dual specificity phosphatase
Occurring in:
  1. Dual specificity protein phosphatase 5
IPR008343
Domain description: Mitogen-activated protein (MAP) kinase phosphatase
Occurring in:
  1. Dual specificity protein phosphatase 5
IPR029021
Domain description: Protein-tyrosine phosphatase-like
Occurring in:
  1. Dual specificity protein phosphatase 5
IPR020422
Domain description: Dual specificity protein phosphatase domain
Occurring in:
  1. Dual specificity protein phosphatase 5
IPR003595
Domain description: Protein-tyrosine phosphatase, catalytic
Occurring in:
  1. Dual specificity protein phosphatase 5
IPR000340
Domain description: Dual specificity phosphatase, catalytic domain
Occurring in:
  1. Dual specificity protein phosphatase 5

Structure domain

CATH CATH domain
3.90.190.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Protein-Tyrosine Phosphatase; Chain A
Homology: Protein tyrosine phosphatase superfamily
Occurring in:
  1. Dual specificity protein phosphatase 5
1 copy of CATH domain 3.90.190.10 (Protein-Tyrosine Phosphatase; Chain A) in Dual specificity protein phosphatase 5 in PDB 2g6z.