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Crystal structure of human DUSP5

X-ray diffraction
2.7Å resolution
PDB 2g6z coloured by chain and viewed from the front.
PDB 2g6z coloured by chain and viewed from the side.
PDB 2g6z coloured by chain and viewed from the top.
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: homo trimer
Accessible surface area: 19200 Å2
Buried surface area: 4000 Å2
Dissociation area: 1,300 Å2
Dissociation energy (ΔGdiss): -7 kcal/mol
Dissociation entropy (TΔSdiss): 23 kcal/mol
Interface energy (ΔGint): -127 kcal/mol
Symmetry number: 1

Macromolecules

Dual specificity protein phosphatase 5
Chains: A, B, C
Length: 211 amino acids
Theoretical weight: 23.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16690 (Residues: 178-384; Coverage: 54%)
Gene names: DUSP5, VH3
Pfam: Dual specificity phosphatase, catalytic domain
InterPro:
CATH: Protein tyrosine phosphatase superfamily
PDB 2g6z contains 3 copies of Dual specificity protein phosphatase 5 in assembly 1. This protein is highlighted and viewed from the front.
PDB 2g6z contains 3 copies of Dual specificity protein phosphatase 5 in assembly 1. This protein is highlighted and viewed from the side.
PDB 2g6z contains 3 copies of Dual specificity protein phosphatase 5 in assembly 1. This protein is highlighted and viewed from the top.
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