X-ray diffraction
1.75Å resolution

Human alpha-Phosphomannomutase 1 with D-mannose 1-phosphate and Mg2+ cofactor bound


Function and Biology Details

Reaction catalysed:
Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Phosphomannomutase 1 Chain: A
Molecule details ›
Chain: A
Length: 262 amino acids
Theoretical weight: 29.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q92871 (Residues: 1-262; Coverage: 100%)
Gene names: PMM1, PMMH22
Sequence domains: Eukaryotic phosphomannomutase
Structure domains:

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P43212
Unit cell:
a: 51.39Å b: 51.39Å c: 214.603Å
α: 90° β: 90° γ: 90°
R R work R free
0.204 0.202 0.24
Expression system: Escherichia coli