2fol

X-ray diffraction
2.63Å resolution

Crystal structure of human RAB1A in complex with GDP

Released:
Source organism: Homo sapiens
Entry authors: Wang J, Tempel W, Shen Y, Shen L, Arrowsmith C, Edwards A, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-1A Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 21.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62820 (Residues: 6-177; Coverage: 84%)
Gene names: RAB1, RAB1A
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P3221
Unit cell:
a: 75.79Å b: 75.79Å c: 49.08Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.252
Expression system: Escherichia coli