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The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 364-367

X-ray diffraction
1.6Å resolution
PDB entry 2foj coloured by chain, front view.
PDB entry 2foj coloured by chain, side view.
PDB entry 2foj coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ubiquitin carboxyl-terminal hydrolase 7 and Cellular tumor antigen p53
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Multimeric state: hetero dimer
Accessible surface area: 7903.03 Å2
Buried surface area: 778.91 Å2
Dissociation area: 389.46 Å2
Dissociation energy (ΔGdiss): -1.61 kcal/mol
Dissociation entropy (TΔSdiss): 6.23 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138124

Macromolecules

Ubiquitin carboxyl-terminal hydrolase 7
Chain: A
Length: 155 amino acids
Theoretical weight: 18.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q93009 (Residues: 54-205; Coverage: 14%)
Gene names: HAUSP, USP7
Pfam: MATH domain
InterPro:
CATH: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Ubiquitin carboxyl-terminal hydrolase 7 in PDB entry 2foj, assembly 1, front view.
Ubiquitin carboxyl-terminal hydrolase 7 in PDB entry 2foj, assembly 1, side view.
Ubiquitin carboxyl-terminal hydrolase 7 in PDB entry 2foj, assembly 1, top view.
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Cellular tumor antigen p53
Chain: B
Length: 7 amino acids
Theoretical weight: 687 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04637 (Residues: 361-367; Coverage: 2%)
Gene names: P53, TP53
Cellular tumor antigen p53 in PDB entry 2foj, assembly 1, front view.
Cellular tumor antigen p53 in PDB entry 2foj, assembly 1, side view.
Cellular tumor antigen p53 in PDB entry 2foj, assembly 1, top view.
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