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Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor

X-ray diffraction
2.95Å resolution
PDB 2fhy coloured by chain and viewed from the front.
PDB 2fhy coloured by chain and viewed from the side.
PDB 2fhy coloured by chain and viewed from the top.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer
Accessible surface area: 42600 Å2
Buried surface area: 18900 Å2
Dissociation area: 8,200 Å2
Dissociation energy (ΔGdiss): 82 kcal/mol
Dissociation entropy (TΔSdiss): 43 kcal/mol
Interface energy (ΔGint): -111 kcal/mol
Symmetry number: 4

Macromolecules

Fructose-1,6-bisphosphatase 1
Chains: A, D, H, L
Length: 374 amino acids
Theoretical weight: 40.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09467 (Residues: 1-338; Coverage: 100%)
Gene names: FBP, FBP1
Pfam:
InterPro:
CATH:
PDB 2fhy contains 4 copies of Fructose-1,6-bisphosphatase 1 in assembly 1. This protein is highlighted and viewed from the front.
PDB 2fhy contains 4 copies of Fructose-1,6-bisphosphatase 1 in assembly 1. This protein is highlighted and viewed from the side.
PDB 2fhy contains 4 copies of Fructose-1,6-bisphosphatase 1 in assembly 1. This protein is highlighted and viewed from the top.
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