Structure analysis

Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor

X-ray diffraction
2.95Å resolution
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer
Accessible surface area: 42600 Å2
Buried surface area: 18900 Å2
Dissociation area: 8,200 Å2
Dissociation energy (ΔGdiss): 82 kcal/mol
Dissociation entropy (TΔSdiss): 43 kcal/mol
Interface energy (ΔGint): -111 kcal/mol
Symmetry number: 4

Macromolecules

Chains: A, D, H, L
Length: 374 amino acids
Theoretical weight: 40.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09467 (Residues: 1-338; Coverage: 100%)
Gene names: FBP, FBP1
Pfam:
InterPro:
CATH:

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