› 2ffq

X-ray diffraction
1.78Å resolution

The crystal structure of human neuronal Rab6B in its active GTPgS-bound form

Released:
DOI: 10.2210/pdb2ffq/pdb
PDB entry 2ffq coloured by chain, front view.
PDB entry 2ffq coloured by chain, side view.
PDB entry 2ffq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human neuronal Rab6B in the active and inactive form.
Garcia-Saez I, Tcherniuk S, Kozielski F
Acta Crystallogr D Biol Crystallogr 62 725-33 (2006)
PMID: 16790928

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192570 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-6B Chain: A
Molecule details ›
Chain: A
Length: 171 amino acids
Theoretical weight: 19.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NRW1 (Residues: 13-174; Coverage: 78%)
Gene name: RAB6B
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand GSP 1 x GSP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P212121
Unit cell:
a: 35.885Å b: 60.983Å c: 63.685Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.202
Expression system: Escherichia coli BL21(DE3)

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Citations

3 review citations

A survey on prediction of specificity-determining sites in proteins.
Chakraborty et al. (2015)
2 more

2 mentions without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)
1 more