› › Function and Biology

Structure of the E203Q mutant of the Cl-/H+ exchanger CLC-ec1 from E.Coli

Source organisms:
Biochemical function: chloride:proton antiporter activity
Biological process: cellular stress response to acidic pH
Cellular component: membrane

Quick links

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00654
Domain description: Voltage gated chloride channel
Occurring in:
  1. H(+)/Cl(-) exchange transporter ClcA
The deposited structure of PDB entry 2fed contains 2 copies of Pfam domain PF00654 (Voltage gated chloride channel) in H(+)/Cl(-) exchange transporter ClcA. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001807
Domain description: Chloride channel, voltage gated
Occurring in:
  1. H(+)/Cl(-) exchange transporter ClcA
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Fab fragment, heavy chain
  2. Fab fragment, light chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Fab fragment, heavy chain
  2. Fab fragment, light chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Fab fragment, heavy chain
  2. Fab fragment, light chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Fab fragment, heavy chain
  2. Fab fragment, light chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Fab fragment, heavy chain
  2. Fab fragment, light chain
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Fab fragment, heavy chain
  2. Fab fragment, light chain
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Fab fragment, light chain
IPR014743
Domain description: Chloride channel, core
Occurring in:
  1. H(+)/Cl(-) exchange transporter ClcA

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Fab fragment, heavy chain
  2. Fab fragment, light chain
The deposited structure of PDB entry 2fed contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Fab fragment, heavy chain. Showing 2 copies in chain C.
The deposited structure of PDB entry 2fed contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Fab fragment, light chain. Showing 2 copies in chain D.
1.10.3080.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Clc chloride channel
Homology: Clc chloride channel
Occurring in:
  1. H(+)/Cl(-) exchange transporter ClcA
The deposited structure of PDB entry 2fed contains 2 copies of CATH domain 1.10.3080.10 (Clc chloride channel) in H(+)/Cl(-) exchange transporter ClcA. Showing 1 copy in chain A.
SCOP SCOP annotations
48942
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Immunoglobulin
Occurring in:
  1. Fab fragment, light chain
The deposited structure of PDB entry 2fed contains 2 copies of SCOP domain 48942 (C1 set domains (antibody constant domain-like)) in Fab fragment, light chain. Showing 1 copy in chain D.
48727
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Immunoglobulin
Occurring in:
  1. Fab fragment, light chain
The deposited structure of PDB entry 2fed contains 2 copies of SCOP domain 48727 (V set domains (antibody variable domain-like)) in Fab fragment, light chain. Showing 1 copy in chain D.
69912
Class: Membrane and cell surface proteins and peptides
Fold: Clc chloride channel
Superfamily: Clc chloride channel
Occurring in:
  1. H(+)/Cl(-) exchange transporter ClcA
The deposited structure of PDB entry 2fed contains 2 copies of SCOP domain 69912 (Clc chloride channel) in H(+)/Cl(-) exchange transporter ClcA. Showing 1 copy in chain A.

Quick links