X-ray diffraction
2.4Å resolution

WRN exonuclease, Mn complex


Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Werner syndrome ATP-dependent helicase Chain: A
Molecule details ›
Chain: A
Length: 205 amino acids
Theoretical weight: 23.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q14191 (Residues: 38-236; Coverage: 14%)
Gene names: RECQ3, RECQL2, WRN
Sequence domains: 3'-5' exonuclease
Structure domains: Ribonuclease H-like superfamily/Ribonuclease H

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P3221
Unit cell:
a: 80.971Å b: 80.971Å c: 93.184Å
α: 90° β: 90° γ: 120°
R R work R free
0.237 0.237 0.277
Expression system: Escherichia coli