› 2f8m

X-ray diffraction
2.09Å resolution

Ribose 5-phosphate isomerase from Plasmodium falciparum

Released:
DOI: 10.2210/pdb2f8m/pdb
PDB entry 2f8m coloured by chain, front view.
PDB entry 2f8m coloured by chain, side view.
PDB entry 2f8m coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Structure of ribose 5-phosphate isomerase from Plasmodium falciparum.
Holmes MA, Buckner FS, Van Voorhis WC, Verlinde CL, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Zucker F, Schoenfeld LW, Earnest TN, Hol WG, Merritt EA
Acta Crystallogr Sect F Struct Biol Cryst Commun 62 427-31 (2006)
PMID: 16682767

Function and Biology Details

Reaction catalysed: 
D-ribose 5-phosphate = D-ribulose 5-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184663 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribose-5-phosphate isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 244 amino acids
Theoretical weight: 27.23 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8I3W2 (Residues: 1-236; Coverage: 100%)
Gene name: PF3D7_0514600
Sequence domains: Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P21212
Unit cell:
a: 93.689Å b: 136.23Å c: 45.011Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.208 0.272
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.
Stincone et al. (2015)
1 more

7 mentions without citation

Is it time for artificial intelligence to predict the function of natural products based on 2D-structure.
Liu et al. (2019)
6 more