X-ray diffraction
1.7Å resolution

Crystal structure of Bifunctional coenzyme A synthase (CoA synthase): (18044849) from MUS MUSCULUS at 1.70 A resolution

Source organism: Mus musculus
Entry author: Joint Center for Structural Genomics (JCSG)

Function and Biology Details

Reactions catalysed:
ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
ATP + 3'-dephospho-CoA = ADP + CoA
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Bifunctional coenzyme A synthase Chain: A
Molecule details ›
Chain: A
Length: 281 amino acids
Theoretical weight: 31.45 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: Q9DBL7 (Residues: 295-563; Coverage: 48%)
Gene names: Coasy, Ukr1
Sequence domains: Dephospho-CoA kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: C2
Unit cell:
a: 101.04Å b: 32.37Å c: 95.2Å
α: 90° β: 110.24° γ: 90°
R R work R free
0.18 0.178 0.211
Expression system: Escherichia coli