› 2f6r

X-ray diffraction
1.7Å resolution

Crystal structure of Bifunctional coenzyme A synthase (CoA synthase): (18044849) from MUS MUSCULUS at 1.70 A resolution

Released:
DOI: 10.2210/pdb2f6r/pdb
PDB 2f6r coloured by chain and viewed from the front.
PDB 2f6r coloured by chain and viewed from the side.
PDB 2f6r coloured by chain and viewed from the top.
Source organism: Mus musculus
Entry author: Joint Center for Structural Genomics (JCSG)

Function and Biology Details

Reactions catalysed: 
ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
ATP + 3'-dephospho-CoA = ADP + CoA
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional coenzyme A synthase Chain: A
Molecule details ›
Chain: A
Length: 281 amino acids
Theoretical weight: 31.45 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9DBL7 (Residues: 295-563; Coverage: 48%)
Gene names: Coasy, Ukr1
Sequence domains: Dephospho-CoA kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand ACO 1 x ACO
Ligand UNL 1 x UNL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: C2
Unit cell:
a: 101.04Å b: 32.37Å c: 95.2Å
α: 90° β: 110.24° γ: 90°
R-values:
R R work R free
0.18 0.178 0.211
Expression system: Escherichia coli

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