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GRP94 N-terminal Domain bound to geldanamycin

X-ray diffraction
2.35Å resolution
PDB entry 2exl coloured by chain, front view.
PDB entry 2exl coloured by chain, side view.
PDB entry 2exl coloured by chain, top view.
Source organism: Canis lupus familiaris
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Endoplasmin
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Multimeric state: homo dimer
Accessible surface area: 20395.96 Å2
Buried surface area: 5274.28 Å2
Dissociation area: 597.94 Å2
Dissociation energy (ΔGdiss): -11.36 kcal/mol
Dissociation entropy (TΔSdiss): 12.5 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154246

Macromolecules

Endoplasmin
Chains: A, B
Length: 236 amino acids
Theoretical weight: 26.51 KDa
Source organism: Canis lupus familiaris
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P41148 (Residues: 69-337; Coverage: 30%)
Gene names: GRP94, HSP90B1, HSPC4, TRA1
Pfam: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
InterPro:
CATH: Histidine kinase-like ATPase, C-terminal domain
SCOP: Heat shock protein 90, HSP90, N-terminal domain
Endoplasmin in PDB entry 2exl, assembly 1, front view.
Endoplasmin in PDB entry 2exl, assembly 1, side view.
Endoplasmin in PDB entry 2exl, assembly 1, top view.
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