X-ray diffraction
2.68Å resolution

Structure of Rv1264N, the regulatory domain of the mycobacterial adenylyl cylcase Rv1264, at pH 5.3


Function and Biology Details

Reaction catalysed:
ATP = 3',5'-cyclic AMP + diphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
pH-sensitive adenylate cyclase Rv1264 Chains: A, B
Molecule details ›
Chains: A, B
Length: 222 amino acids
Theoretical weight: 24.17 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P9WMU9 (Residues: 1-207; Coverage: 52%)
Gene names: MTCY50.18c, Rv1264
Sequence domains: Adenylate cyclase regulatory domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 120.403Å b: 52.976Å c: 89.399Å
α: 90° β: 133.73° γ: 90°
R R work R free
0.231 0.229 0.265
Expression system: Escherichia coli BL21(DE3)