2eqg

Solution NMR

Solution structure of the first A20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3

Released:
Source organism: Homo sapiens
Entry authors: Zhang HP, Hayahsi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
A20p50 Chain: A
Molecule details ›
Chain: A
Length: 49 amino acids
Theoretical weight: 5.21 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P21580 (Residues: 381-416; Coverage: 5%)
Gene names: OTUD7C, TNFAIP3
Sequence domains: A20-like zinc finger
Structure domains: CD2-Gal4

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided