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Solution structure of the second Phorbol esters/diacylglycerol binding domain of human Protein kinase C alpha type

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.7.11.13: Protein kinase C

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (diacylglycerol-dependent)
Alternative Name(s):
  • CPKC
  • CPKC-alpha
  • CPKC-beta
  • CPKC-gamma
  • Calcium-dependent protein kinase C
  • Calcium-independent protein kinase C
  • Calcium/phospholipid dependent protein kinase
  • NPKC
  • NPKC-delta
  • NPKC-epsilon
  • NPKC-eta
  • NPKC-theta
  • PKC
  • PKC-alpha
  • PKC-beta
  • PKC-delta
  • PKC-epsilon
  • PKC-gamma
  • PKC-zeta
  • Pkc1p
  • Protein kinase C-epsilon
  • STK24

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00130
Domain description: Phorbol esters/diacylglycerol binding domain (C1 domain)
Occurring in:
  1. Protein kinase C alpha type
The deposited structure of PDB entry 2eli contains 1 copy of Pfam domain PF00130 (Phorbol esters/diacylglycerol binding domain (C1 domain)) in Protein kinase C alpha type. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR020454
Domain description: Diacylglycerol/phorbol-ester binding
Occurring in:
  1. Protein kinase C alpha type
IPR002219
Domain description: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Occurring in:
  1. Protein kinase C alpha type
IPR015727
Domain description: Protein kinase C mu-related
Occurring in:
  1. Protein kinase C alpha type
IPR046349
Domain description: C1-like domain superfamily
Occurring in:
  1. Protein kinase C alpha type

Structure domain

CATH CATH domain
3.30.60.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Homology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Occurring in:
  1. Protein kinase C alpha type
The deposited structure of PDB entry 2eli contains 1 copy of CATH domain 3.30.60.20 (Wheat Germ Agglutinin (Isolectin 2); domain 1) in Protein kinase C alpha type. Showing 1 copy in chain A.

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