EC 7.1.1.9: Cytochrome-c oxidase
Reaction catalysed:
4 ferrocytochrome c + O(2) + 8 H(+)(Side 1) = 4 ferricytochrome c + 4 H(2)O(Side 2)
Systematic name:
Ferrocytochrome-c:oxygen oxidoreductase
Alternative Name(s):
- Complex IV (mitochondrial electron transport)
- Cytochrome a3
- Cytochrome aa3
- Cytochrome ba(3)
- Cytochrome bb3
- Cytochrome caa(3)
- Cytochrome cbb(3)
- Cytochrome oxidase
- Ferrocytochrome c oxidase
- Indophenol oxidase
- Indophenolase
- NADH cytochrome c oxidase
- Warburg's respiratory enzyme
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR037169
Domain description:
Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily
Occurring in:
Occurring in:
IPR036549
Domain description:
Cytochrome c oxidase subunit 6B/Cytochrome c oxidase assembly factor 6-like superfamily
Occurring in:
Occurring in:
IPR036257
Domain description:
Cytochrome C oxidase subunit II, transmembrane domain superfamily
Occurring in:
Occurring in:
Structure domains
CATH domains
4.10.81.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Cytochrome C Oxidase; Chain M
Homology:
Cytochrome c oxidase, subunit 8
Occurring in:
4.10.49.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Cytochrome C Oxidase; Chain L
Homology:
Cytochrome c oxidase subunit VIIc
Occurring in:
4.10.51.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Cytochrome C Oxidase; Chain K
Homology:
Cytochrome C Oxidase, chain K
Occurring in:
4.10.91.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Cytochrome C Oxidase; Chain J
Homology:
Cytochrome c oxidase, subunit VIIa
Occurring in:
4.10.93.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Cytochrome C Oxidase; Chain I
Homology:
Mitochondrial cytochrome c oxidase subunit VIc/VIIs
Occurring in:
1.10.10.140
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Arc Repressor Mutant, subunit A
Homology:
Cytochrome c oxidase, subunit VIb
Occurring in:
4.10.95.10
Class:
Few Secondary Structures
Architecture:
Irregular
Topology:
Cytochrome C Oxidase; Chain G
Homology:
Cytochrome c oxidase, subunit VIa
Occurring in:
2.60.11.10
Class:
Mainly Beta
Architecture:
Sandwich
Topology:
Cytochrome C Oxidase; Chain F
Homology:
Cytochrome c oxidase, subunit Vb
Occurring in:
1.25.40.40
Class:
Mainly Alpha
Architecture:
Alpha Horseshoe
Topology:
Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology:
Cytochrome c oxidase, subunit Va/VI
Occurring in:
1.10.442.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Cytochrome C Oxidase; Chain D
Homology:
Cytochrome c oxidase subunit IV
Occurring in:
1.20.120.80
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Four Helix Bundle (Hemerythrin (Met), subunit A)
Homology:
Cytochrome c oxidase, subunit III, four-helix bundle
Occurring in:
1.10.287.70
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Helix Hairpins
Homology:
Helix Hairpins
Occurring in:
2.60.40.420
Class:
Mainly Beta
Architecture:
Sandwich
Topology:
Immunoglobulin-like
Homology:
Cupredoxins - blue copper proteins
Occurring in:
1.10.287.90
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Helix Hairpins
Homology:
Helix Hairpins
Occurring in:
SCOP annotations
81430
Class:
Membrane and cell surface proteins and peptides
Fold:
Single transmembrane helix
Superfamily:
Mitochondrial cytochrome c oxidase subunit VIIIb (aka IX)
Occurring in:
81426
Class:
Membrane and cell surface proteins and peptides
Fold:
Single transmembrane helix
Superfamily:
Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)
Occurring in:
81422
Class:
Membrane and cell surface proteins and peptides
Fold:
Single transmembrane helix
Superfamily:
Mitochondrial cytochrome c oxidase subunit VIIb
Occurring in:
81418
Class:
Membrane and cell surface proteins and peptides
Fold:
Single transmembrane helix
Superfamily:
Mitochondrial cytochrome c oxidase subunit VIIa
Occurring in:
81414
Class:
Membrane and cell surface proteins and peptides
Fold:
Single transmembrane helix
Superfamily:
Mitochondrial cytochrome c oxidase subunit VIc
Occurring in:
47695
Class:
All alpha proteins
Fold:
Cytochrome c oxidase subunit h
Superfamily:
Cytochrome c oxidase subunit h
Occurring in:
81410
Class:
Membrane and cell surface proteins and peptides
Fold:
Single transmembrane helix
Superfamily:
Mitochondrial cytochrome c oxidase subunit VIa
Occurring in:
48480
Class:
All alpha proteins
Fold:
alpha-alpha superhelix
Superfamily:
Cytochrome c oxidase subunit E
Occurring in:
81405
Class:
Membrane and cell surface proteins and peptides
Fold:
Single transmembrane helix
Superfamily:
Mitochondrial cytochrome c oxidase subunit IV
Occurring in:
81451
Class:
Membrane and cell surface proteins and peptides
Fold:
Cytochrome c oxidase subunit III-like
Superfamily:
Cytochrome c oxidase subunit III-like
Occurring in:
81463
Class:
Membrane and cell surface proteins and peptides
Fold:
Transmembrane helix hairpin
Superfamily:
Cytochrome c oxidase subunit II-like, transmembrane region
Occurring in:
81441
Class:
Membrane and cell surface proteins and peptides
Fold:
Cytochrome c oxidase subunit I-like
Superfamily:
Cytochrome c oxidase subunit I-like
Occurring in: