X-ray diffraction
2.4Å resolution

Crystal structure of the extracellular domain of human CD38

Source organism: Homo sapiens
Entry authors: Kukimoto-Niino M, Nureki O, Murayama K, Shirouzu M, Katada T, Hara-Yokoyama M, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reactions catalysed:
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 256 amino acids
Theoretical weight: 29.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P28907 (Residues: 45-300; Coverage: 85%)
Gene name: CD38
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44B2
Spacegroup: P21
Unit cell:
a: 57.593Å b: 51.164Å c: 101.135Å
α: 90° β: 97.53° γ: 90°
R R work R free
0.203 0.203 0.256
Expression system: Escherichia coli