X-ray diffraction
3Å resolution

Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Mast/stem cell growth factor receptor Kit Chain: A
Molecule details ›
Chain: A
Length: 524 amino acids
Theoretical weight: 59.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P10721 (Residues: 1-519; Coverage: 52%)
Gene names: KIT, SCFR
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X26C
Spacegroup: R3
Unit cell:
a: 162.249Å b: 162.249Å c: 67.586Å
α: 90° β: 90° γ: 120°
R R work R free
0.256 0.254 0.295
Expression system: Spodoptera frugiperda