2e6i

Solution NMR

Solution structure of the BTK motif of tyrosine-protein kinase ITK from human

Released:
Source organism: Homo sapiens
Entry authors: Li H, Tochio N, Koshiba S, Watanabe S, Harada T, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ITK/TSK Chain: A
Molecule details ›
Chain: A
Length: 64 amino acids
Theoretical weight: 7.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q08881 (Residues: 113-169; Coverage: 9%)
Gene names: EMT, ITK, LYK
Sequence domains: BTK motif
Structure domains: btk motif of tyrosine-protein kinase itk

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 87%
Refinement method: torsion angle dynamics
Chemical shifts: BMR11093  
Expression system: Not provided