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Solution structure of cytoskeletal protein in complex with tubulin tail

Solution NMR
PDB entry 2e4h coloured by chain, ensemble of 20 models, front view.
PDB entry 2e4h coloured by chain, ensemble of 20 models, side view.
PDB entry 2e4h coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Detyrosinated tubulin alpha-1B chain and CAP-Gly domain-containing linker protein 1
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Multimeric state: hetero dimer
Accessible surface area: 5219.53 Å2
Buried surface area: 678.48 Å2
Dissociation area: 339.24 Å2
Dissociation energy (ΔGdiss): -1.5 kcal/mol
Dissociation entropy (TΔSdiss): 6.81 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151774

Macromolecules

CAP-Gly domain-containing linker protein 1
Chain: A
Length: 98 amino acids
Theoretical weight: 10.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P30622 (Residues: 203-300; Coverage: 7%)
Gene names: CLIP1, CYLN1, RSN
Pfam: CAP-Gly domain
InterPro:
CATH: CAP Gly-rich-like domain
SCOP: Cap-Gly domain
CAP-Gly domain-containing linker protein 1 in PDB entry 2e4h, assembly 1, front view.
CAP-Gly domain-containing linker protein 1 in PDB entry 2e4h, assembly 1, side view.
CAP-Gly domain-containing linker protein 1 in PDB entry 2e4h, assembly 1, top view.
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Detyrosinated tubulin alpha-1B chain
Chain: B
Length: 36 amino acids
Theoretical weight: 4.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68363 (Residues: 416-451; Coverage: 8%)
Gene name: TUBA1B
InterPro: Tubulin, C-terminal
Detyrosinated tubulin alpha-1B chain in PDB entry 2e4h, assembly 1, front view.
Detyrosinated tubulin alpha-1B chain in PDB entry 2e4h, assembly 1, side view.
Detyrosinated tubulin alpha-1B chain in PDB entry 2e4h, assembly 1, top view.
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