PDBe 2e1f

X-ray diffraction
2Å resolution

Crystal structure of the HRDC Domain of Human Werner Syndrome Protein, WRN

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of the HRDC domain of human Werner syndrome protein, WRN.
J. Biol. Chem. 282 2717-28 (2007)
PMID: 17148451

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Werner syndrome ATP-dependent helicase Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 11.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14191 (Residues: 1142-1242; Coverage: 7%)
Gene names: RECQ3, RECQL2, WRN
Sequence domains: HRDC domain
Structure domains: DNA polymerase; domain 1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: P6222
Unit cell:
a: 61.664Å b: 61.664Å c: 136.683Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.248 0.248 0.255
Expression system: Escherichia coli