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Crystal structure of the HRDC Domain of Human Werner Syndrome Protein, WRN

Source organism: Homo sapiens
Biochemical function: nucleic acid binding
Biological process: cellular metabolic process
Cellular component: not assigned

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EC 3.6.4.12: DNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (DNA helix unwinding)
Alternative Name(s):
  • 3' to 5' DNA helicase
  • 3'-5' DNA helicase
  • 3'-5' PfDH
  • 5' to 3' DNA helicase
  • AvDH1
  • BACH1 helicase
  • BLM protein
  • BRCA1-associated C-terminal helicase
  • BcMCM
  • CeWRN-1
  • DNA helicase 120
  • DNA helicase A
  • DNA helicase E
  • DNA helicase II
  • DNA helicase III
  • DNA helicase RECQL5'
  • DNA helicase VI
  • Dbp9p
  • DmRECQ5
  • DnaB
  • DnaB helicase E1
  • HHcsA
  • HPif1
  • Hel E
  • Helicase DnaB
  • Helicase HDH IV
  • Helicase domain of bacteriophage T7 gene 4 protein helicase
  • Hmi1p
  • MCM helicase
  • MCM protein
  • MER3 helicase
  • MER3 protein
  • MPH1
  • PDH120
  • PIF1
  • PcrA
  • PcrA helicase
  • PfDH A
  • Pfh1p
  • UvrD

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00570
Domain description: HRDC domain
Occurring in:
  1. Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
The deposited structure of PDB entry 2e1e contains 1 copy of Pfam domain PF00570 (HRDC domain) in Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002121
Domain description: HRDC domain
Occurring in:
  1. Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
IPR010997
Domain description: HRDC-like superfamily
Occurring in:
  1. Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
IPR044876
Domain description: HRDC domain superfamily
Occurring in:
  1. Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Structure domain

CATH CATH domain
1.10.150.80
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA polymerase; domain 1
Homology: HRDC domain
Occurring in:
  1. Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
The deposited structure of PDB entry 2e1e contains 1 copy of CATH domain 1.10.150.80 (DNA polymerase; domain 1) in Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN. Showing 1 copy in chain A.
SCOP SCOP annotation
47820
Class: All alpha proteins
Fold: SAM domain-like
Superfamily: HRDC-like
Occurring in:
  1. Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
The deposited structure of PDB entry 2e1e contains 1 copy of SCOP domain 47820 (HRDC domain from helicases) in Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN. Showing 1 copy in chain A.

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