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Crystal structure of Probable phosphoribosylglycinamide formyl transferase from Pyrococcus horikoshii OT3 complexed with ADP

Source organism: Pyrococcus horikoshii OT3
Biochemical function: metal ion binding
Biological process: purine ribonucleotide biosynthetic process
Cellular component: cytosol

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EC 6.3.1.21: Phosphoribosylglycinamide formyltransferase 2

Reaction catalysed:
ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + phosphate + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide
Systematic name:
Formate:N(1)-(5-phospho-beta-D-ribosyl)glycinamide ligase (ADP-forming)
Alternative Name(s):
  • 5'-phosphoribosylglycinamide transformylase 2
  • GAR transformylase 2
  • GAR transformylase T
  • GART2
  • Glycinamide ribonucleotide transformylase 2

GO terms

Sequence families

Pfam Protein families (Pfam)
PF21244
Domain description: PurT, C-terminal
Occurring in:
  1. Formate-dependent phosphoribosylglycinamide formyltransferase
The deposited structure of PDB entry 2dwc contains 2 copies of Pfam domain PF21244 (PurT, C-terminal) in Formate-dependent phosphoribosylglycinamide formyltransferase. Showing 1 copy in chain B.

PF02222
Domain description: ATP-grasp domain
Occurring in:
  1. Formate-dependent phosphoribosylglycinamide formyltransferase
The deposited structure of PDB entry 2dwc contains 2 copies of Pfam domain PF02222 (ATP-grasp domain) in Formate-dependent phosphoribosylglycinamide formyltransferase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR005862
Domain description: Formate-dependent phosphoribosylglycinamide formyltransferase
Occurring in:
  1. Formate-dependent phosphoribosylglycinamide formyltransferase
IPR011054
Domain description: Rudiment single hybrid motif
Occurring in:
  1. Formate-dependent phosphoribosylglycinamide formyltransferase
IPR013815
Domain description: ATP-grasp fold, subdomain 1
Occurring in:
  1. Formate-dependent phosphoribosylglycinamide formyltransferase
IPR003135
Domain description: ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
Occurring in:
  1. Formate-dependent phosphoribosylglycinamide formyltransferase
IPR011761
Domain description: ATP-grasp fold
Occurring in:
  1. Formate-dependent phosphoribosylglycinamide formyltransferase
IPR016185
Domain description: Pre-ATP-grasp domain superfamily
Occurring in:
  1. Formate-dependent phosphoribosylglycinamide formyltransferase

Structure domains

CATH CATH domains
3.30.470.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: D-amino Acid Aminotransferase; Chain A, domain 1
Homology: ATP-grasp fold, B domain
Occurring in:
  1. Formate-dependent phosphoribosylglycinamide formyltransferase
The deposited structure of PDB entry 2dwc contains 2 copies of CATH domain 3.30.470.20 (D-amino Acid Aminotransferase; Chain A, domain 1) in Formate-dependent phosphoribosylglycinamide formyltransferase. Showing 1 copy in chain B.
3.30.1490.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dna Ligase; domain 1
Homology: ATP-grasp fold, A domain
Occurring in:
  1. Formate-dependent phosphoribosylglycinamide formyltransferase
The deposited structure of PDB entry 2dwc contains 2 copies of CATH domain 3.30.1490.20 (Dna Ligase; domain 1) in Formate-dependent phosphoribosylglycinamide formyltransferase. Showing 1 copy in chain B.
3.40.50.20
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Formate-dependent phosphoribosylglycinamide formyltransferase
The deposited structure of PDB entry 2dwc contains 2 copies of CATH domain 3.40.50.20 (Rossmann fold) in Formate-dependent phosphoribosylglycinamide formyltransferase. Showing 1 copy in chain B.

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