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Structure of PH1917 protein with the complex of ITP from Pyrococcus horikoshii

Source organism: Pyrococcus horikoshii
Biochemical function: nucleoside triphosphate diphosphatase activity
Biological process: purine nucleoside triphosphate catabolic process
Cellular component: cytosol

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EC 3.6.1.66: XTP/dITP diphosphatase

Reaction catalysed:
ITP + H(2)O = IMP + diphosphate
Systematic name:
XTP/dITP diphosphohydrolase (diphosphate-forming)
Alternative Name(s):
  • Hypoxanthine/xanthine dNTP pyrophosphatase
  • RdgB (gene name)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01725
Domain description: Ham1 family
Occurring in:
  1. dITP/XTP pyrophosphatase
The deposited structure of PDB entry 2dvo contains 1 copy of Pfam domain PF01725 (Ham1 family) in dITP/XTP pyrophosphatase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002637
Domain description: RdgB/HAM1
Occurring in:
  1. dITP/XTP pyrophosphatase
IPR029001
Domain description: Inosine triphosphate pyrophosphatase-like
Occurring in:
  1. dITP/XTP pyrophosphatase
IPR020922
Domain description: dITP/XTP pyrophosphatase
Occurring in:
  1. dITP/XTP pyrophosphatase

Structure domain

CATH CATH domain
3.90.950.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Maf protein
Homology: Maf protein
Occurring in:
  1. dITP/XTP pyrophosphatase
The deposited structure of PDB entry 2dvo contains 1 copy of CATH domain 3.90.950.10 (Maf protein) in dITP/XTP pyrophosphatase. Showing 1 copy in chain A.
SCOP SCOP annotation
52973
Class: Alpha and beta proteins (a/b)
Fold: Anticodon-binding domain-like
Superfamily: ITPase-like
Occurring in:
  1. dITP/XTP pyrophosphatase
The deposited structure of PDB entry 2dvo contains 1 copy of SCOP domain 52973 (ITPase (Ham1)) in dITP/XTP pyrophosphatase. Showing 1 copy in chain A.

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