› 2dpk

X-ray diffraction
2.5Å resolution

The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger

Released:
DOI: 10.2210/pdb2dpk/pdb
PDB 2dpk coloured by chain and viewed from the front.
PDB 2dpk coloured by chain and viewed from the side.
PDB 2dpk coloured by chain and viewed from the top.
Source organism: Canis lupus familiaris
Primary publication:
The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif.
Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J
J. Biol. Chem. 281 21577-81 (2006)
PMID: 16774926

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium/calcium exchanger 1 Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 16.69 KDa
Source organism: Canis lupus familiaris
Expression system: Escherichia coli
UniProt:
  • Canonical: P23685 (Residues: 402-541; Coverage: 15%)
Gene names: NCX1, SLC8A1
Sequence domains: Calx-beta domain
Structure domains: Immunoglobulin-like

Ligands and Environments

3 bound ligands:
Ligand CA 4 x CA
Ligand GAI 1 x GAI
Ligand EPE 1 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21212
Unit cell:
a: 59.624Å b: 45.524Å c: 57.269Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.222 0.284
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Ca2+ Transportome and the Interorganelle Communication in Hepatocellular Carcinoma.
Lai et al. (2022)
12 more

14 mentions without citation

Structural Features of Ion Transport and Allosteric Regulation in Sodium-Calcium Exchanger (NCX) Proteins.
Giladi et al. (2016)
13 more