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Crystal structure of TACE in complex with TAPI-2

X-ray diffraction
1.7Å resolution
PDB entry 2ddf coloured by chain, front view.
PDB entry 2ddf coloured by chain, side view.
PDB entry 2ddf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Disintegrin and metalloproteinase domain-containing protein 17
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Multimeric state: monomeric
Accessible surface area: 11854.42 Å2
Buried surface area: 1201.8 Å2
Dissociation area: 100.15 Å2
Dissociation energy (ΔGdiss): -2.04 kcal/mol
Dissociation entropy (TΔSdiss): -0.38 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-160275
Assembly 2 (preferred)
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Assembly Name: Disintegrin and metalloproteinase domain-containing protein 17
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Multimeric state: monomeric
Accessible surface area: 11700.35 Å2
Buried surface area: 1925.81 Å2
Dissociation area: 96.02 Å2
Dissociation energy (ΔGdiss): -2.78 kcal/mol
Dissociation entropy (TΔSdiss): -0.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-160275

Macromolecules

Disintegrin and metalloproteinase domain-containing protein 17
Chains: A, B
Length: 257 amino acids
Theoretical weight: 29.01 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P78536 (Residues: 218-474; Coverage: 32%)
Gene names: ADAM17, CSVP, TACE
Pfam: Metallo-peptidase family M12B Reprolysin-like
InterPro:
CATH: Collagenase (Catalytic Domain)
Disintegrin and metalloproteinase domain-containing protein 17 in PDB entry 2ddf, assembly 2, front view.
Disintegrin and metalloproteinase domain-containing protein 17 in PDB entry 2ddf, assembly 2, side view.
Disintegrin and metalloproteinase domain-containing protein 17 in PDB entry 2ddf, assembly 2, top view.
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