2d8s

Solution NMR

Solution structure of the RING domain of the human cellular modulator of immune recognition protein

Released:
Source organism: Homo sapiens
Entry authors: Miyamoto K, Kigawa T, Tomizawa T, Koshiba S, Inoue M, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase MARCHF8 Chain: A
Molecule details ›
Chain: A
Length: 80 amino acids
Theoretical weight: 8.62 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q5T0T0 (Residues: 70-136; Coverage: 23%)
Gene names: MARCH8, MARCHF8, MIR, RNF178
Sequence domains: RING-variant domain
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Chemical shifts: BMR11325  
Expression system: Not provided