PDBe 2d10

X-ray diffraction
2.5Å resolution

Crystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptide

Released:
Source organisms:
Primary publication:
Structural basis for NHERF recognition by ERM proteins.
Structure 14 777-89 (2006)
PMID: 16615918

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Radixin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 312 amino acids
Theoretical weight: 36.92 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P26043 (Residues: 1-310; Coverage: 53%)
Gene name: Rdx
Sequence domains:
Structure domains:
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 28 amino acids
Theoretical weight: 3.41 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O14745 (Residues: 331-358; Coverage: 8%)
Gene names: NHERF, NHERF1, SLC9A3R1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL40B2
Spacegroup: P212121
Unit cell:
a: 69.388Å b: 146.277Å c: 177.763Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.229 0.268
Expression systems:
  • Escherichia coli
  • Not provided