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Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus.

Asojo OA, Schott EJ, Vasta GR, Silva AM
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 1072-5 (2006)
Cited: 10 times
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Abstract

Perkinsus marinus, a facultative intracellular parasite of the eastern oyster Crassostrea virginica, is responsible for mass mortalities of oyster populations. P. marinus trophozoites survive and proliferate within oyster hemocytes, invading most tissues and fluids, thus causing a systemic infection that eventually kills the host. The phagocytosis of P. marinus trophozoites lacks a respiratory burst, suggesting that the parasite has mechanisms that actively abrogate the host's oxidative defense responses. One mechanism and the first line of defense against oxidative damage is the dismutation of superoxide radical to molecular oxygen and hydrogen peroxide by superoxide dismutases (SODs). P. marinus possesses two iron-cofactored SODs, PmSOD1 and PmSOD2. Here, the crystallization and X-ray structures of both PmSOD1 and PmSOD2 are presented.

Articles - 2cw3 mentioned but not cited (2)

  1. Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus. Asojo OA, Schott EJ, Vasta GR, Silva AM. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 1072-1075 (2006)
  2. Structures of native and Fe-substituted SOD2 from Saccharomyces cerevisiae. Kang Y, He YX, Zhao MX, Li WF. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 67 1173-1178 (2011)


Reviews citing this publication (2)

  1. Structural, functional, and evolutionary aspects of galectins in aquatic mollusks: From a sweet tooth to the Trojan horse. Vasta GR, Feng C, Bianchet MA, Bachvaroff TR, Tasumi S. Fish Shellfish Immunol. 46 94-106 (2015)
  2. Superoxide dismutases: ancient enzymes and new insights. Miller AF. FEBS Lett. 586 585-595 (2012)

Articles citing this publication (6)

  1. The Alveolate Perkinsus marinus: biological insights from EST gene discovery. Joseph SJ, Fernández-Robledo JA, Gardner MJ, El-Sayed NM, Kuo CH, Schott EJ, Wang H, Kissinger JC, Vasta GR. BMC Genomics 11 228 (2010)
  2. Transfection of the protozoan parasite Perkinsus marinus. Fernández-Robledo JA, Lin Z, Vasta GR. Mol. Biochem. Parasitol. 157 44-53 (2008)
  3. Perkinsus marinus superoxide dismutase 2 (PmSOD2) localizes to single-membrane subcellular compartments. Fernández-Robledo JA, Schott EJ, Vasta GR. Biochem. Biophys. Res. Commun. 375 215-219 (2008)
  4. Differential expression of serine protease inhibitors 1 and 2 in Crassostrea corteziensis and C. virginica infected with Perkinsus marinus. Gutiérrez-Rivera JN, Arcos-Ortega GF, Luna-González A, Rodríguez-Jaramillo MC, Arechiga-Carvajal ET, Vázquez-Juárez R. Dis. Aquat. Org. 112 185-197 (2015)
  5. Comparative Time-Scale Gene Expression Analysis Highlights the Infection Processes of Two Amoebophrya Strains. Farhat S, Florent I, Noel B, Kayal E, Da Silva C, Bigeard E, Alberti A, Labadie K, Corre E, Aury JM, Rombauts S, Wincker P, Guillou L, Porcel BM. Front Microbiol 9 2251 (2018)
  6. Identification and Molecular Characterization of Superoxide Dismutases Isolated From A Scuticociliate Parasite: Physiological Role in Oxidative Stress. Folgueira I, Lamas J, de Felipe AP, Sueiro RA, Leiro JM. Sci Rep 9 13329 (2019)


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