X-ray diffraction
2.7Å resolution

Crystal structure of human thioredoxin reductase 1

Source organism: Homo sapiens
Entry authors: Debreczeni JE, Johansson C, Kavanagh K, Savitsky P, Sundstrom M, Arrowsmith C, Weigelt J, Edwards A, von Delft F, Oppermann U

Function and Biology Details

Reaction catalysed:
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Thioredoxin reductase 1, cytoplasmic Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 521 amino acids
Theoretical weight: 57.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q16881 (Residues: 150-649; Coverage: 77%)
  • Best match: Q16881-5 (Residues: 1-499)
Gene names: GRIM12, KDRF, TXNRD1
Sequence domains:
Structure domains:

Ligands and Environments

Cofactor: Ligand FAD 6 x FAD
No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P2
Unit cell:
a: 89.756Å b: 149.651Å c: 146.789Å
α: 90° β: 91.96° γ: 90°
R R work R free
0.205 0.203 0.248
Expression system: Escherichia coli BL21(DE3)