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The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue

X-ray diffraction
1.7Å resolution
PDB entry 2cch coloured by chain, front view.
PDB entry 2cch coloured by chain, side view.
PDB entry 2cch coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclin A2-CDK2 complex and Cell division control protein 6 homolog
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Multimeric state: hetero trimer
Accessible surface area: 24391.86 Å2
Buried surface area: 5844.19 Å2
Dissociation area: 677.79 Å2
Dissociation energy (ΔGdiss): 3.38 kcal/mol
Dissociation entropy (TΔSdiss): 8.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148906
Assembly 2
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Assembly Name: Cyclin A2-CDK2 complex and Cell division control protein 6 homolog
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Multimeric state: hetero trimer
Accessible surface area: 24331.95 Å2
Buried surface area: 5024.74 Å2
Dissociation area: 671.71 Å2
Dissociation energy (ΔGdiss): 3.05 kcal/mol
Dissociation entropy (TΔSdiss): 8.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148906

Macromolecules

Cyclin-dependent kinase 2
Chains: A, C
Length: 299 amino acids
Theoretical weight: 34.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Cyclin-dependent kinase 2 in PDB entry 2cch, assembly 1, front view.
Cyclin-dependent kinase 2 in PDB entry 2cch, assembly 1, side view.
Cyclin-dependent kinase 2 in PDB entry 2cch, assembly 1, top view.
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Cyclin-A2
Chains: B, D
Length: 260 amino acids
Theoretical weight: 29.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20248 (Residues: 173-432; Coverage: 60%)
Gene names: CCN1, CCNA, CCNA2
Pfam:
InterPro:
CATH: Cyclin-like
SCOP: Cyclin
Cyclin-A2 in PDB entry 2cch, assembly 1, front view.
Cyclin-A2 in PDB entry 2cch, assembly 1, side view.
Cyclin-A2 in PDB entry 2cch, assembly 1, top view.
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Cell division control protein 6 homolog
Chains: E, F
Length: 12 amino acids
Theoretical weight: 1.46 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q99741 (Residues: 89-100; Coverage: 2%)
Gene names: CDC18L, CDC6
Cell division control protein 6 homolog in PDB entry 2cch, assembly 1, front view.
Cell division control protein 6 homolog in PDB entry 2cch, assembly 1, side view.
Cell division control protein 6 homolog in PDB entry 2cch, assembly 1, top view.
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