X-ray diffraction
2.1Å resolution

Structure of human adenylate kinase 2

Source organism: Homo sapiens
Entry authors: Bunkoczi G, Filippakopoulos P, Debreczeni JE, Turnbull A, Papagrigoriou E, Savitsky P, Colebrook S, von Delft F, Arrowsmith C, Edwards A, Sundstrom M, Weigelt J, Knapp S

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Adenylate kinase 2, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 26.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P54819 (Residues: 1-239; Coverage: 100%)
Gene names: ADK2, AK2
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 45.042Å b: 49.26Å c: 127.001Å
α: 90° β: 90° γ: 90°
R R work R free
0.198 0.194 0.274
Expression system: Escherichia coli BL21(DE3)