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Crystal Structure of (SR) Calcium-ATPase E2(Tg) with partially occupied AMPPCP site

Source organism: Oryctolagus cuniculus
Biochemical function: metal ion binding
Biological process: calcium ion import into sarcoplasmic reticulum
Cellular component: sarcoplasmic reticulum membrane

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EC 7.2.2.10: P-type Ca(2+) transporter

Reaction catalysed:
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Systematic name:
ATP phosphohydrolase (P-type, Ca(2+)-transporting)
Alternative Name(s):
  • Ca(2+)-pumping ATPase
  • Ca(2+)-transporting ATPase
  • Calcium pump
  • Calcium-translocating P-type ATPase
  • Plasma membrane Ca-ATPase
  • Sarco(endo)plasmic reticulum Ca(2+)-ATPase
  • Sarcoplasmic reticulum ATPase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00689
Domain description: Cation transporting ATPase, C-terminus
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
The deposited structure of PDB entry 2c8k contains 1 copy of Pfam domain PF00689 (Cation transporting ATPase, C-terminus) in Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. Showing 1 copy in chain A.

PF00702
Domain description: haloacid dehalogenase-like hydrolase
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
The deposited structure of PDB entry 2c8k contains 1 copy of Pfam domain PF00702 (haloacid dehalogenase-like hydrolase) in Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. Showing 1 copy in chain A.

PF13246
Domain description: Cation transport ATPase (P-type)
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
The deposited structure of PDB entry 2c8k contains 1 copy of Pfam domain PF13246 (Cation transport ATPase (P-type)) in Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. Showing 1 copy in chain A.

PF00122
Domain description: E1-E2 ATPase
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
The deposited structure of PDB entry 2c8k contains 1 copy of Pfam domain PF00122 (E1-E2 ATPase) in Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. Showing 1 copy in chain A.

PF00690
Domain description: Cation transporter/ATPase, N-terminus
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
The deposited structure of PDB entry 2c8k contains 1 copy of Pfam domain PF00690 (Cation transporter/ATPase, N-terminus) in Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001757
Domain description: P-type ATPase
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
IPR023299
Domain description: P-type ATPase, cytoplasmic domain N
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
IPR004014
Domain description: Cation-transporting P-type ATPase, N-terminal
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
IPR006068
Domain description: Cation-transporting P-type ATPase, C-terminal
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
IPR018303
Domain description: P-type ATPase, phosphorylation site
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
IPR044492
Domain description: P-type ATPase, haloacid dehalogenase domain
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
IPR008250
Domain description: P-type ATPase, A domain superfamily
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
IPR005782
Domain description: P-type ATPase, subfamily IIA, SERCA-type
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
IPR023298
Domain description: P-type ATPase, transmembrane domain superfamily
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Structure domains

CATH CATH domains
1.20.1110.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Calcium-transporting ATPase, transmembrane domain
Homology: Calcium-transporting ATPase, transmembrane domain
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
The deposited structure of PDB entry 2c8k contains 1 copy of CATH domain 1.20.1110.10 (Calcium-transporting ATPase, transmembrane domain) in Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. Showing 1 copy in chain A.
3.40.50.1000
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HAD superfamily/HAD-like
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
The deposited structure of PDB entry 2c8k contains 1 copy of CATH domain 3.40.50.1000 (Rossmann fold) in Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. Showing 1 copy in chain A.
2.70.150.10
Class: Mainly Beta
Architecture: Distorted Sandwich
Topology: Calcium-transporting ATPase, cytoplasmic transduction domain A
Homology: Calcium-transporting ATPase, cytoplasmic transduction domain A
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
The deposited structure of PDB entry 2c8k contains 1 copy of CATH domain 2.70.150.10 (Calcium-transporting ATPase, cytoplasmic transduction domain A) in Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. Showing 1 copy in chain A.
3.40.1110.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Calcium-transporting ATPase, cytoplasmic domain N
Homology: Calcium-transporting ATPase, cytoplasmic domain N
Occurring in:
  1. Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
The deposited structure of PDB entry 2c8k contains 1 copy of CATH domain 3.40.1110.10 (Calcium-transporting ATPase, cytoplasmic domain N) in Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. Showing 1 copy in chain A.

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