› 2c8k

X-ray diffraction
2.8Å resolution

Crystal Structure of (SR) Calcium-ATPase E2(Tg) with partially occupied AMPPCP site

Released:
DOI: 10.2210/pdb2c8k/pdb
PDB 2c8k coloured by chain and viewed from the front.
PDB 2c8k coloured by chain and viewed from the side.
PDB 2c8k coloured by chain and viewed from the top.
Source organism: Oryctolagus cuniculus
Primary publication:
Modulatory and catalytic modes of ATP binding by the calcium pump.
Jensen AM, Sørensen TL, Olesen C, Møller JV, Nissen P
EMBO J. 25 2305-14 (2006)
PMID: 16710301

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Chain: A
Molecule details ›
Chain: A
Length: 994 amino acids
Theoretical weight: 109.6 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P04191 (Residues: 1-993; Coverage: 99%)
  • Best match: P04191-2 (Residues: 1-994)
Gene name: ATP2A1
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand TG1 1 x TG1
Ligand ACP 1 x ACP
Ligand MG 1 x MG
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P41212
Unit cell:
a: 71.34Å b: 71.34Å c: 587.99Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.252 0.308

Quick links

Citations

16 review citations

Targeting oncogenic Notch signaling with SERCA inhibitors.
Pagliaro et al. (2021)
15 more

10 mentions without citation

Lipid interaction sites on channels, transporters and receptors: Recent insights from molecular dynamics simulations.
Hedger et al. (2016)
9 more