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Solution structure of the C4 zinc finger domain of HDM2.

Yu GW, Allen MD, Andreeva A, Fersht AR, Bycroft M
Protein Sci 15 384-9 (2006)
Cited: 28 times
EuropePMC logo PMID: 16385008

Abstract

HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the tumor suppressor p53. Here, we report the determination of the solution structure of the C4 zinc finger domain of HDM2 using multidimensional NMR. The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix followed by four beta-strands, which shares significant structural similarity to the zinc ribbon protein family. Family based sequence analysis identified two putative binding sites, one of which resembles an RNA binding motif.

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  2. Thioesterases: a new perspective based on their primary and tertiary structures. Cantu DC, Chen Y, Reilly PJ. Protein Sci 19 1281-1295 (2010)


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  1. DNA topoisomerases: harnessing and constraining energy to govern chromosome topology. Schoeffler AJ, Berger JM. Q. Rev. Biophys. 41 41-101 (2008)

Articles citing this publication (25)

  1. The central region of HDM2 provides a second binding site for p53. Yu GW, Rudiger S, Veprintsev D, Freund S, Fernandez-Fernandez MR, Fersht AR. Proc. Natl. Acad. Sci. U.S.A. 103 1227-1232 (2006)
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  4. The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences. Loughlin FE, Mansfield RE, Vaz PM, McGrath AP, Setiyaputra S, Gamsjaeger R, Chen ES, Morris BJ, Guss JM, Mackay JP. Proc. Natl. Acad. Sci. U.S.A. 106 5581-5586 (2009)
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  6. MDMX contains an autoinhibitory sequence element. Bista M, Petrovich M, Fersht AR. Proc. Natl. Acad. Sci. U.S.A. 110 17814-17819 (2013)
  7. Structure of human J-type co-chaperone HscB reveals a tetracysteine metal-binding domain. Bitto E, Bingman CA, Bittova L, Kondrashov DA, Bannen RM, Fox BG, Markley JL, Phillips GN. J. Biol. Chem. 283 30184-30192 (2008)
  8. Intrinsically unstructured domains of Arf and Hdm2 form bimolecular oligomeric structures in vitro and in vivo. Sivakolundu SG, Nourse A, Moshiach S, Bothner B, Ashley C, Satumba J, Lahti J, Kriwacki RW. J. Mol. Biol. 384 240-254 (2008)
  9. The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors. Stapf C, Cartwright E, Bycroft M, Hofmann K, Buchberger A. J. Biol. Chem. 286 38670-38678 (2011)
  10. Molecular characterization of the Ran-binding zinc finger domain of Nup153. Higa MM, Alam SL, Sundquist WI, Ullman KS. J Biol Chem 282 17090-17100 (2007)
  11. Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation. Zhang Q, Xiao H, Chai SC, Hoang QQ, Lu H. J. Biol. Chem. 286 38264-38274 (2011)
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  13. Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif. Worrall EG, Wawrzynow B, Worrall L, Walkinshaw M, Ball KL, Hupp TR. J Chem Biol 2 113-129 (2009)
  14. Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation. Zheng J, Lang Y, Zhang Q, Cui D, Sun H, Jiang L, Chen Z, Zhang R, Gao Y, Tian W, Wu W, Tang J, Chen Z. Genes Dev. 29 1524-1534 (2015)
  15. The effects of phosphomimetic lid mutation on the thermostability of the N-terminal domain of MDM2. Worrall EG, Worrall L, Blackburn E, Walkinshaw M, Hupp TR. J. Mol. Biol. 398 414-428 (2010)
  16. Crystallographic and biochemical analysis of the Ran-binding zinc finger domain. Partridge JR, Schwartz TU. J. Mol. Biol. 391 375-389 (2009)
  17. Structural characterization of the DAXX N-terminal helical bundle domain and its complex with Rassf1C. Escobar-Cabrera E, Lau DK, Giovinazzi S, Ishov AM, McIntosh LP. Structure 18 1642-1653 (2010)
  18. The chaperone ClpX stimulates expression of Staphylococcus aureus protein A by Rot dependent and independent pathways. Jelsbak L, Ingmer H, Valihrach L, Cohn MT, Christiansen MH, Kallipolitis BH, Frees D. PLoS ONE 5 e12752 (2010)
  19. Autoactivation of the MDM2 E3 ligase by intramolecular interaction. Cheng Q, Song T, Chen L, Chen J. Mol. Cell. Biol. 34 2800-2810 (2014)
  20. Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry. Hernychova L, Man P, Verma C, Nicholson J, Sharma CA, Ruckova E, Teo JY, Ball K, Vojtesek B, Hupp TR. Proteomics 13 2512-2525 (2013)
  21. Splicing up mdm2 for cancer proteome diversity. Okoro DR, Rosso M, Bargonetti J. Genes Cancer 3 311-319 (2012)
  22. The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex. Schrader N, Koerner C, Koessmeier K, Bangert JA, Wittinghofer A, Stoll R, Vetter IR. Structure 16 1116-1125 (2008)
  23. The PR/SET domain in PRDM4 is preceded by a zinc knuckle. Briknarová K, Atwater DZ, Glicken JM, Maynard SJ, Ness TE. Proteins 79 2341-2345 (2011)
  24. Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation. Yan W, Scoumanne A, Jung YS, Xu E, Zhang J, Zhang Y, Ren C, Sun P, Chen X. Genes Dev. 30 522-534 (2016)
  25. Redox properties of Cys2His2 and Cys4 zinc fingers determined by electrospray ionization mass spectrometry. Smirnova J, Kabin E, Tõugu V, Palumaa P. FEBS Open Bio 8 923-931 (2018)


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