Function and Biology

Solution structure of the C4 zinc-finger domain of HDM2

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00641
Domain description: Zn-finger in Ran binding protein and others
Occurring in:
  1. E3 ubiquitin-protein ligase Mdm2
The deposited structure of PDB entry 2c6a contains 1 copy of Pfam domain PF00641 (Zn-finger in Ran binding protein and others) in E3 ubiquitin-protein ligase Mdm2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001876
Domain description: Zinc finger, RanBP2-type
Occurring in:
  1. E3 ubiquitin-protein ligase Mdm2
IPR036443
Domain description: Zinc finger, RanBP2-type superfamily
Occurring in:
  1. E3 ubiquitin-protein ligase Mdm2

Structure domain

CATH CATH domain
2.30.30.380
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: Zn-finger domain of Sec23/24
Occurring in:
  1. E3 ubiquitin-protein ligase Mdm2
The deposited structure of PDB entry 2c6a contains 1 copy of CATH domain 2.30.30.380 (SH3 type barrels.) in E3 ubiquitin-protein ligase Mdm2. Showing 1 copy in chain A.
SCOP SCOP annotation
90210
Class: Small proteins
Fold: Rubredoxin-like
Superfamily: Ran binding protein zinc finger-like
Occurring in:
  1. E3 ubiquitin-protein ligase Mdm2
The deposited structure of PDB entry 2c6a contains 1 copy of SCOP domain 90210 (Ran binding protein zinc finger-like) in E3 ubiquitin-protein ligase Mdm2. Showing 1 copy in chain A.