Solution NMR

Solution structure of the C4 zinc-finger domain of HDM2

Source organism: Homo sapiens
Primary publication:
Solution structure of the C4 zinc finger domain of HDM2.
Protein Sci. 15 384-9 (2006)
PMID: 16385008

Function and Biology Details

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
E3 ubiquitin-protein ligase Mdm2 Chain: A
Molecule details ›
Chain: A
Length: 46 amino acids
Theoretical weight: 5.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q00987 (Residues: 290-335; Coverage: 9%)
Gene name: MDM2
Sequence domains: Zn-finger in Ran binding protein and others
Structure domains: Rubrerythrin, domain 2

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli BL21(DE3)