› 2c3y

X-ray diffraction
1.93Å resolution

CRYSTAL STRUCTURE OF THE RADICAL FORM OF PYRUVATE:FERREDOXIN OXIDOREDUCTASE FROM Desulfovibrio africanus

Released:
DOI: 10.2210/pdb2c3y/pdb
PDB 2c3y coloured by chain and viewed from the front.
PDB 2c3y coloured by chain and viewed from the side.
PDB 2c3y coloured by chain and viewed from the top.
Source organism: Desulfocurvibacter africanus
Entry authors: Cavazza C, Contreras-Martel C, Pieulle L, Chabriere E, Hatchikian EC, Fontecilla-Camps JC

Function and Biology Details

Reaction catalysed: 
Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments


Cofactor: Ligand HTL 2 x HTL
4 bound ligands:
Ligand SF4 6 x SF4
Ligand MG 2 x MG
Ligand CA 2 x CA
Ligand CO2 2 x CO2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 86.081Å b: 145.639Å c: 211.619Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.186 0.228

Quick links

Citations

5 review citations

A structural phylogeny for understanding 2-oxoacid oxidoreductase function.
Gibson et al. (2016)
4 more

1 mention without citation

Binding site for coenzyme A revealed in the structure of pyruvate:ferredoxin oxidoreductase from Moorella thermoacetica.
Chen et al. (2018)