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X-ray diffraction
2.05Å resolution

CRYSTAL STRUCTURE OF ACHBP FROM APLYSIA CALIFORNICA IN complex with lobeline

Released:
DOI: 10.2210/pdb2bys/pdb
PDB 2bys coloured by chain and viewed from the front.
PDB 2bys coloured by chain and viewed from the side.
PDB 2bys coloured by chain and viewed from the top.
Source organism: Aplysia californica
Entry authors: Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, Bourne Y

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neur_chan_LBD domain-containing protein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 227 amino acids
Theoretical weight: 25.85 KDa
Source organism: Aplysia californica
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8WSF8 (Residues: 16-236; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

1 bound ligand:
Ligand LOB 10 x LOB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P1
Unit cell:
a: 75.764Å b: 85.731Å c: 117.318Å
α: 89.95° β: 97.33° γ: 106.64°
R-values:
R R work R free
0.217 0.216 0.258
Expression system: Homo sapiens

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Citations

72 review citations

Photopharmacology of Ion Channels through the Light of the Computational Microscope.
Nin-Hill et al. (2021)
71 more

16 mentions without citation

Size matters in activation/inhibition of ligand-gated ion channels.
Du et al. (2012)
15 more