X-ray diffraction
2.5Å resolution

crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 44.65 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
  • Canonical: Q15119 (Residues: 14-407; Coverage: 97%)
  • Best match: Q15119-2 (Residues: 1-343)
Gene names: PDHK2, PDK2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P64
Unit cell:
a: 110.699Å b: 110.699Å c: 84.609Å
α: 90° β: 90° γ: 120°
R R work R free
0.233 0.233 0.24
Expression system: Trichoplusia ni