2br8

X-ray diffraction
2.4Å resolution

Crystal Structure of Acetylcholine-binding Protein (AChBP) from Aplysia californica in complex with an alpha-conotoxin PnIA variant

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Neur_chan_LBD domain-containing protein Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 217 amino acids
Theoretical weight: 24.69 KDa
Source organism: Aplysia californica
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8WSF8 (Residues: 20-236; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain
Alpha-conotoxin PnIA Chains: F, G, H, I, J
Molecule details ›
Chains: F, G, H, I, J
Length: 17 amino acids
Theoretical weight: 1.68 KDa
Source organism: Conus pennaceus
Expression system: Not provided
UniProt:
  • Canonical: P50984 (Residues: 1-16; Coverage: 100%)

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 67.473Å b: 80.085Å c: 134.043Å
α: 90° β: 93.2° γ: 90°
R-values:
R R work R free
0.201 0.198 0.25
Expression systems:
  • Spodoptera frugiperda
  • Not provided