Function and Biology

SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR

Source organisms:
Biochemical function: myosin VI head/neck binding
Biological process: photoreceptor cell axon guidance
Cellular component: mitotic spindle pole

EC 2.7.11.18: Myosin-light-chain kinase

Reaction catalysed:
ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate
Systematic name:
ATP:[myosin-light-chain] O-phosphotransferase
Alternative Name(s):
  • ATP:myosin-light-chain O-phosphotransferase
  • Calcium/calmodulin-dependent myosin light chain kinase
  • MLCK
  • MLCkase
  • Myosin kinase
  • Myosin light chain kinase
  • Myosin light chain protein kinase
  • Myosin light-chain kinase
  • Myosin light-chain kinase (phosphorylating)
  • STK18
  • Smooth-muscle-myosin-light-chain kinase
  • [Myosin-light-chain] kinase

Sequence family

Pfam Protein family (Pfam)
PF13499
Domain description: EF-hand domain pair
Occurring in:
  1. Calmodulin
The deposited structure of PDB entry 2bbm contains 2 copies of Pfam domain PF13499 (EF-hand domain pair) in Calmodulin. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR002048
Domain description: EF-hand domain
Occurring in:
  1. Calmodulin
IPR018247
Domain description: EF-Hand 1, calcium-binding site
Occurring in:
  1. Calmodulin
IPR011992
Domain description: EF-hand domain pair
Occurring in:
  1. Calmodulin

Structure domain

CATH CATH domain
1.10.238.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Recoverin; domain 1
Homology: EF-hand
Occurring in:
  1. Calmodulin
The deposited structure of PDB entry 2bbm contains 2 copies of CATH domain 1.10.238.10 (Recoverin; domain 1) in Calmodulin. Showing 2 copies in chain A.
SCOP SCOP annotation
47502
Class: All alpha proteins
Fold: EF Hand-like
Superfamily: EF-hand
Occurring in:
  1. Calmodulin
The deposited structure of PDB entry 2bbm contains 1 copy of SCOP domain 47502 (Calmodulin-like) in Calmodulin. Showing 1 copy in chain A.