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cytokine receptor complex

X-ray diffraction
2.3Å resolution
PDB entry 2b5i coloured by chain, front view.
PDB entry 2b5i coloured by chain, side view.
PDB entry 2b5i coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 32650.35 Å2
Buried surface area: 7352.28 Å2
Dissociation area: 2,962.18 Å2
Dissociation energy (ΔGdiss): -11.87 kcal/mol
Dissociation entropy (TΔSdiss): 37.47 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134426

Macromolecules

Interleukin-2
Chain: A
Length: 133 amino acids
Theoretical weight: 15.44 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P60568 (Residues: 21-153; Coverage: 100%)
Gene name: IL2
Pfam: Interleukin 2
InterPro:
CATH: Growth Hormone; Chain: A;
SCOP: Short-chain cytokines
Interleukin-2 in PDB entry 2b5i, assembly 1, front view.
Interleukin-2 in PDB entry 2b5i, assembly 1, side view.
Interleukin-2 in PDB entry 2b5i, assembly 1, top view.
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Interleukin-2 receptor subunit beta
Chain: B
Length: 214 amino acids
Theoretical weight: 24.76 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P14784 (Residues: 27-240; Coverage: 41%)
Gene names: IL15RB, IL2RB
Pfam: Interleukin-2 receptor subunit beta N-terminal domain 1
InterPro:
CATH: Immunoglobulins
SCOP: Fibronectin type III
Interleukin-2 receptor subunit beta in PDB entry 2b5i, assembly 1, front view.
Interleukin-2 receptor subunit beta in PDB entry 2b5i, assembly 1, side view.
Interleukin-2 receptor subunit beta in PDB entry 2b5i, assembly 1, top view.
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Cytokine receptor common subunit gamma
Chain: C
Length: 199 amino acids
Theoretical weight: 23.91 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P31785 (Residues: 56-254; Coverage: 57%)
Gene name: IL2RG
Pfam:
InterPro:
CATH: Immunoglobulins
SCOP: Fibronectin type III
Cytokine receptor common subunit gamma in PDB entry 2b5i, assembly 1, front view.
Cytokine receptor common subunit gamma in PDB entry 2b5i, assembly 1, side view.
Cytokine receptor common subunit gamma in PDB entry 2b5i, assembly 1, top view.
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Interleukin-2 receptor subunit alpha
Chain: D
Length: 217 amino acids
Theoretical weight: 24.57 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01589 (Residues: 22-238; Coverage: 87%)
Gene name: IL2RA
Pfam: Sushi repeat (SCR repeat)
InterPro:
CATH:
SCOP: Complement control module/SCR domain
Interleukin-2 receptor subunit alpha in PDB entry 2b5i, assembly 1, front view.
Interleukin-2 receptor subunit alpha in PDB entry 2b5i, assembly 1, side view.
Interleukin-2 receptor subunit alpha in PDB entry 2b5i, assembly 1, top view.
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